BELOTERO® INTENSE with Lidocaine

BELOTERO® INTENSE with Lidocaine is a cross-linked hyaluronic acid dermal filler designed for the correction of deep facial wrinkles and folds, as well as for volume enhancement in areas such as the lips, cheeks, and chin. It contains 25.5 mg/mL of cross-linked sodium hyaluronate and 3.0 mg/mL of lidocaine hydrochloride, providing both effective volumization and patient comfort during the procedure.

Manufactured using Cohesive Polydensified Matrix (CPM®) technology, this filler ensures smooth integration into the skin, offering natural-looking results with minimal risk of lumps or irregularities. The effects of BELOTERO® INTENSE with Lidocaine typically last between 9 to 12 months, depending on individual factors such as skin type, age, and lifestyle.

BELOTERO® INTENSE with Lidocaine should be administered by licensed healthcare professionals trained in facial anatomy and injection techniques.

Key Features:

• Injection depth: Deep dermis
  
• Needle size: 27G½” needles
  

Protocol Details:

• Injection techniques: Linear threading, serial puncture, fanning, or cross-hatching
  
• Volume per session: Varies based on treatment area and desired correction
  
• Post-injection care: Gentle massage to ensure even distribution
  
• Touch-up: Optional, typically 2 to 4 weeks after initial treatment

Indications:

• Deep facial wrinkles and folds, including:
  
  • Nasolabial folds
    
  • Marionette lines
    
  • Oral commissures
    
• Volume enhancement in areas such as:
  
  • Lips
    
  • Cheeks
    
  • Chin
    
  • Jawline
    

Contraindications:

• Severe allergies or history of anaphylaxis
  
• Hypersensitivity to hyaluronic acid, lidocaine, or amide-type anesthetics
  
• Pregnancy or breastfeeding
  
• Active skin infections or inflammation at the injection site
  

Side Effects:

• Common: Redness, swelling, bruising, tenderness, itching
  
• Rare: Nodules, granulomas, discoloration, vascular occlusion

Each 1 mL syringe contains:

• Cross-linked sodium hyaluronate: 25.5 mg/mL
  
• Lidocaine hydrochloride: 3.0 mg/mL
  
• Phosphate buffer: pH 7

Package Contents:

• 1 pre-filled syringe (1 mL)
  
• 2 sterile 27G½” needles
  
• Package insert with detailed instructions
• 2 traceability labels for record-keeping

While generally well-tolerated, BELOTERO® INTENSE with Lidocaine may cause side effects.

Common Side Effects:

• Injection site reactions: Redness, swelling, bruising, tenderness, itching
  
• Duration: Typically resolve within 1 to 2 weeks
  

Rare Side Effects:

• Nodules or granulomas
  
• Discoloration
  
• Vascular occlusion, leading to more serious complications

Storage Conditions:

• Temperature: Store between 2°C and 25°C
  
• Avoid: Freezing and exposure to direct sunlight
  
• Packaging: Keep in original packaging until use
  
• Shelf life: Do not use beyond the expiration date indicated on the packaging