INTRALINE® M4 PLUS

INTRALINE® M4 PLUS is a high-density monophasic hyaluronic acid (HA) dermal filler formulated for the treatment of deep-set wrinkles and facial volume enhancement, including cheek contouring, chin augmentation, jawline sculpting, and non-surgical rhinoplasty. This advanced filler contains 24 mg/mL of HA and 3 mg/mL of lidocaine for enhanced comfort. Engineered using monodensified technology and BDDE cross-linking, M4 PLUS offers maximum projection, stability, and long-lasting results for demanding structural corrections.

• Applications: Cheeks, chin, jawline, nose, and high-definition lip contouring
• Filler Type: Monophasic, high-viscosity for structural support
• Effect Duration: Typically 6–12 months, depending on the area treated
• Ideal Use: Deep volumization and contour definition

M4 PLUS is designed for deep subcutaneous injection, allowing precise volumization and durable lifting. The dual-needle format supports practitioner flexibility across multiple treatment zones.

• Injection Level: Lower subcutaneous plane
• Technique: Linear threading, bolus, and deep depot
• Needle Size: 25G and 27G needles
• Syringe Volume: 1.1 mL prefilled syringe
• Comfort Additive: Lidocaine 3 mg/mL
• Viscosity Profile: High-density gel for stability and sculpting

This filler is indicated for deep dermal corrections and facial contouring, making it ideal for structural enhancement where support and definition are critical.

Indications:

• Chin augmentation
• Jawline sculpting
• Cheekbone enhancement
• Nasal bridge reshaping (non-surgical rhinoplasty)
• Lip contouring (for enhanced definition)

Contraindications:

• Known allergies to hyaluronic acid or lidocaine
• Active skin infections or inflammatory conditions
• Autoimmune disorders or history of anaphylaxis
• Pregnancy or lactation

Side Effects:

• Common: Redness, bruising, swelling, tenderness at the injection site
• Occasional: Lumps, mild asymmetry, pressure sensation
• Rare: Vascular compromise, granulomas, allergic reaction

M4 PLUS contains non-animal sourced hyaluronic acid, cross-linked with BDDE for stability, and is enriched with lidocaine to ensure patient comfort during injection.

• HA Concentration: 24 mg/mL
• Crosslinking Agent: BDDE (<1 μg/mL)
• Formulation Type: Monophasic, monodensified gel
• Lidocaine Concentration: 3 mg/mL
• HA Origin: Bacterial fermentation (non-animal derived)

Each unit is professionally sealed and sterilized for single-patient use, packaged to support convenient and safe clinical application.

• Contents:
  • 1 x 1.1 mL prefilled syringe
  • 1 x 25G needle
  • 1 x 27G needle
• Packaging: Blister-packed, CE-certified
• Sterility: Assured via validated heat sterilization

Adverse effects are generally mild and temporary when used appropriately. M4 PLUS maintains a strong safety profile in clinical use.

• Mild Effects: Redness, bruising, swelling, tenderness (resolves in 3–7 days)
• Moderate Effects: Local pressure, uneven texture, minor inflammation
• Severe (rare): Infection, granuloma formation, allergic response, or vascular occlusion

Proper storage ensures product stability and safety. Adhere to recommended environmental conditions for best results.

• Storage Temperature: 2–25°C
• Avoid: Freezing, direct sunlight, and moisture
• Shelf Life: Typically 2–3 years from production date
• Note: Use immediately after opening; discard any unused contents