MESOESTETIC® COSMELAN® 2

MESOESTETIC® COSMELAN® 2 is a professional-grade depigmenting cream used as part of the Cosmelan Method, a multi-phase treatment protocol developed to reduce and regulate hyperpigmentation. Designed for home use following the in-office application of Cosmelan 1, this cream works to sustain and enhance the depigmentation process, maintaining results and preventing new pigment formation.

• Maintains results after the professional Cosmelan 1 mask
• Reduces existing pigmentation and inhibits melanin synthesis
• Suitable for all skin phototypes (I–VI) and ethnicities
• Clinically proven to reduce melanin synthesis by up to 81%
• Used by over 1 million patients worldwide

MESOESTETIC® COSMELAN® 2 is applied after the Cosmelan 1 mask, starting 48 hours post-procedure. It plays a crucial role in long-term maintenance of depigmentation and must be used with other companion products in the protocol.

• Phase 2 (first month): Apply 3 times daily — morning, midday, and evening
• Phase 3 (months 2–3): Apply once daily, in the evening
• Always follow with Melan Recovery and Melan 130+ Pigment Control during daytime use
• Apply to clean, dry skin and massage until fully absorbed
• Adjust frequency if extreme sensitivity occurs

Key Features:

• Provides long-term depigmentation control by regulating melanin synthesis
• Must be used with strict adherence to photoprotection guidelines

Protocol Summary:

• 48 hours post-mask: begin application
• 1st month: 3× daily
• Months 2–3: 1× daily (evening)
• Use with Melan Recovery and Melan 130+ for comfort and protection
• Sun protection is mandatory throughout the treatment

MESOESTETIC® COSMELAN® 2 is indicated for the treatment and prevention of various forms of skin hyperpigmentation. It targets the root cause of excess melanin production in the melanocyte, making it suitable for a wide range of pigmentary concerns.

Indications:

• Melasma
• Solar lentigo
• Senile lentigo
• Post-inflammatory hyperpigmentation (PIH)
• Freckles (ephelides)
• Effective for all phototypes, including darker skin tones

Contraindications:

• Pregnancy and breastfeeding
• Active skin infections (e.g., herpes)
• Known allergies to any product ingredients
• Recent facial procedures, such as laser or chemical peels (unless instructed by a professional)

Side Effects:

• Heat or stinging sensation (especially during initial use)
• Redness, dryness, tightness, and flaking of the skin
• Sensitivity to light if sun protection is not used
• These effects are temporary and often indicate treatment activity

MESOESTETIC® COSMELAN® 2 features a potent blend of active depigmenting agents, melanin synthesis inhibitors, and skin-repairing ingredients. The formula is designed to inhibit multiple steps of melanogenesis.

Key Ingredients:

• Azelaic acid – Inhibits tyrosinase activity and reduces melanin production
• Kojic acid – Chelates copper and interferes with melanin synthesis
• Phytic acid – Antioxidant and depigmenting agent
• Arbutin – Inhibits melanin formation by blocking tyrosinase
• Retinol (Vitamin A) – Stimulates cell turnover and exfoliation
• Niacinamide (Vitamin B3) – Reduces melanosome transfer and strengthens the skin barrier

The Cosmelan® pack includes everything required for both in-clinic treatment and at-home maintenance. Cosmelan 2 is one of the four essential components in this comprehensive protocol.

Package Contents:

• Cosmelan 2 Cream – 30g
• Melan Recovery Balm – 50ml
• Melan 130+ Pigment Control SPF – 50ml
• Instructions for use and treatment protocol guide
• Professional-use Cosmelan 1 Mask and Oil Removing Solution are used in-clinic and sold separately

Yes, temporary side effects are common with MESOESTETIC® COSMELAN® 2, especially during the first phase of use. These are signs of active treatment and generally resolve as the skin adapts.

Reported Side Effects:

• Heat and stinging sensation post-application
• Dryness and flaking, especially in the first week
• Redness and skin tightness
• Sensitivity to light, requiring strict sun avoidance
• Risk of irritation increases if sunscreen is not used properly

Management:

• Apply Melan Recovery as often as needed
• Maintain high SPF protection with Melan 130+
• Avoid sun exposure and harsh skincare products

Proper storage of MESOESTETIC® COSMELAN® 2 ensures product efficacy and safety throughout the treatment duration.

Storage Guidelines:

• Store at room temperature, between 15–25°C (59–77°F)
• Keep away from direct sunlight and humidity
• Do not freeze the product
• Ensure the cap is tightly closed after each use
• Keep out of reach of children and avoid contamination with other substances