NUCLEOFILL™ MEDIUM PLUS

NUCLEOFILL™ MEDIUM PLUS is an advanced 2.5% polynucleotide gel designed for the treatment of moderate skin laxity, deep dehydration, and volume loss. Its high-viscosity formulation and molecular weight of 2,500 kDa allow for deeper tissue restructuring, fibroblast activation, and visible improvement in skin density, tone, and elasticity.

Suitable for both corrective and preventive protocols, NUCLEOFILL™ MEDIUM PLUS is particularly effective for areas with moderate tissue degeneration, making it ideal for patients seeking enhanced rejuvenation without resorting to fillers. The treatment provides hydration, antioxidant protection, and collagen synthesis support in a biocompatible and non-allergenic formulation.

This product is injected into the deep dermis using multi-point or 5-point injection techniques.

Key features:

• 2.5% polynucleotide concentration for increased lifting and volumizing effect
• Suitable for medium-to-advanced biorestructuring needs

Administration details:

• Needle: 30G 12 mm, included in packaging
• Injection depth: deep dermis or subdermal
• Dosage: 0.1 mL per point, spaced approximately 1 cm apart
• Recommended protocol: Day 0, Day 15, Day 30, Day 45
• Maintenance session: every 6–8 months

Indications:

• Moderate facial laxity
• Deep dehydration and dull skin
• Scarring, photoaging, or loss of firmness
• Pre-surgical preparation or complement to other treatments

Contraindications:

• Known hypersensitivity to polynucleotides
• Pregnancy or breastfeeding
• Autoimmune disorders
• Active infections or inflammation at injection site

Side effects may include:

• Localized redness, swelling, or bruising
• Temporary discomfort or tightness
• Rare: nodules or allergic reactions

Each syringe contains:

• 2.5% polynucleotide gel
• Molecular weight: 2,500 kDa
• pH: 6.8–7.5
• Viscosity: high (formulated for longer tissue retention)

This high-concentration formulation is derived from purified DNA fragments of natural origin, optimized for long-lasting structural support.

Each product box includes:

• 1 pre-filled syringe of 1.5 mL
• 2 × 30G 12 mm needles
• Sterile packaging
• Instructions for use

Like all injectables, NUCLEOFILL™ MEDIUM PLUS may cause mild, localized side effects, usually resolving within 24–72 hours.

Common side effects:

• Pain, erythema, or edema at injection site
• Mild itching or sensitivity

Rare side effects:

• Inflammatory nodules
• Allergic response
• Vascular complications (very rare)

Storage instructions:

• Store at 2°C to 25°C
• Do not freeze
• Keep away from direct sunlight
• Use immediately after opening
• Discard any unused product