PLINEST® EYE

PLINEST® EYE is a sterile, intradermal injectable gel composed of PN-HPT™ (Polynucleotides – Highly Purified Technology) at a concentration of 15 mg/2 mL, specially formulated for the periorbital region. This low-dose polynucleotide solution is designed to improve skin tone, elasticity, and hydration in the delicate eye contour area. Developed by Mastelli Srl, it is clinically proven to reduce fine lines, crow’s feet, and signs of tired or sagging eyelids, making it ideal for both younger and aging skin requiring gentle, effective rejuvenation.

• Indicated for periocular rejuvenation and skin priming
• Improves fibroblast activity without causing swelling or heaviness
• Validated by 3D imaging and physician-assessed clinical outcomes

Over 90% of patients showed improvement in skin texture

PLINEST® EYE is administered via intradermal injection using microdroplet or linear retrograde techniques. The treatment involves multiple sessions over several weeks for optimal clinical results.

• Injection depth: Intradermal
• Dose per session: 1–2 mL
• Technique:
  • Microdroplet spaced 0.5–1 cm apart
  • Or linear retrograde technique
• Treatment schedule:

1 session every 14–21 days, for a total of 3–4 sessions

PLINEST® EYE is specifically designed for aesthetic improvement of the eye contour area, addressing signs of aging and fatigue. It enhances skin quality, radiance, and firmness in delicate facial zones.

Indications:

• Periocular fine wrinkles and crow’s feet
• Upper eyelid laxity and eyebrow ptosis
• Loss of radiance, firmness, and hydration
• Skin priming before aesthetic treatments (e.g., laser, filler, microneedling)

Contraindications:

• Not specified in the leaflet; general contraindications apply
  • Skin infections or inflammation at the injection site
  • Pregnancy and breastfeeding
  • Hypersensitivity to ingredients

Side Effects:

• No severe adverse reactions reported

Well tolerated in clinical settings, even in sensitive areas

PLINEST® EYE is formulated with a specific low-concentration of polynucleotides optimized for delicate areas such as the eye contour.

• Active ingredient: PN-HPT™ (Polynucleotides Highly Purified Technology)
• Concentration: 15 mg/2 mL
• Form: Sterile, non-pyrogenic, viscoelastic gel
• Biological source: DNA fractions of natural origin

Mechanism: Stimulates fibroblast activity, improves skin elasticity and hydration

The product is packaged for single-use in a sterile medical setting, providing all necessary components for immediate application.

• 1 x 2 mL pre-filled syringe of PLINEST® EYE
• 2 x 30G ½ needles (13 mm)
• Sterile, ready-to-use packaging

Medical device classification: For professional intradermal use only

PLINEST® EYE has shown excellent safety and tolerability, especially important in the sensitive periocular region. Clinical evaluations confirm minimal discomfort and no severe adverse events.

• Over 90% of patients experienced positive clinical results
• No reported cases of swelling, nodules, or long-term reactions
• Suitable for delicate and reactive skin types

Injection-related redness or mild swelling may occur temporarily

PLINEST® EYE should be handled and stored under standard conditions for medical injectables to maintain product stability.

• Storage temperature: 2°C to 25°C
• Do not freeze
• Protect from direct light
• Use immediately after opening – single-use only
• Keep in original packaging until use