PLINEST® HAIR

PLINEST® HAIR is a sterile, injectable viscoelastic gel composed of PN-HPT™ (Polynucleotides – Highly Purified Technology) specifically designed to stimulate hair follicles and support hair and eyebrow regeneration. It is recommended for non-androgen-dependent female hormonal alopecia, working by enhancing scalp trophism, increasing hair density, and prolonging the anagen (growth) phase. Developed by Mastelli Srl, this formulation is also used to prime the skin and boost the effectiveness of adjunctive treatments such as biotin, hyaluronic acid, and carboxytherapy.

• Indicated for scalp and eyebrow bioregeneration
• Clinically validated for female hair loss treatment
• Promotes hydration, follicular revitalization, and new hair growth

Suitable as a standalone or combination therapy

PLINEST® HAIR is administered intradermally using either the microdroplet or linear retrograde technique. The protocol includes an initial intensive phase followed by maintenance sessions.

• Injection depth: Intradermal
• Injection volume: 2 mL per session
• Technique:
  • Microdroplet or linear retrograde technique
• Phase I (initial):
  • 1 session every 7–14 days, total of 4 sessions
• Phase II (maintenance):
  • 1 session every 21–30 days, total of 4 sessions
• Treatment areas: Scalp and eyebrows

PLINEST® HAIR is indicated for women experiencing non-androgen-dependent hormonal alopecia, particularly for cases not linked to systemic diseases. It improves hair density, reduces hair shedding, and enhances scalp health.

Indications:

• Female hormonal hair loss (non-androgenic origin)
• Hair thinning and shedding
• Eyebrow regrowth and densification
• Adjunct to hair transplantation or topical therapies

Contraindications:

• Not explicitly listed in the leaflet; general injectable precautions apply
  • Skin infections or inflammation at the treatment site
  • Pregnancy or breastfeeding
  • Allergy to product components

Side Effects:

• No side effects reported in the clinical study
• Well tolerated by all participants in tested age group (25–65 years)

PLINEST® HAIR is formulated using highly purified polynucleotides to promote scalp trophism and follicular activity without inflammatory effects.

• Active ingredient: PN-HPT™ – 15 mg/2 mL
• Form: Sterile, non-pyrogenic, viscoelastic gel
• Technology: High Purification Technology (PN-HPT™)

Mode of action: Trophic stimulation, anti-inflammatory, fibroblast activation

The product is provided in a ready-to-use sterile format for professional intradermal administration.

• 1 x 2 mL pre-filled syringe
• 2 x 30G ½ needles (13 mm)
• Single-use, sterile packaging

CE-marked medical device

In a clinical evaluation of 20 women, no adverse events were reported. The product is noted for its high tolerability and lack of inflammatory response.

• No side effects observed during a 4-month study
• 72% of patients reported objective improvement in hair loss

High satisfaction and clinical efficacy confirmed by video dermoscopy and trichogram data

To preserve its integrity, PLINEST® HAIR must be stored in stable, sterile conditions.

• Storage temperature: 2°C to 25°C
• Do not freeze
• Keep protected from light
• Use immediately after opening – single-use only